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2024
- Investigating in vivo tumor biomolecular changes following radiation therapy using Raman spectroscopy
Karunakaran V, Dadgar S, Paidi SK, Mordi AF, Lowe WA, Mim UM, Ivers JD, Rodriguez Troncoso JI, McPeake JA, Fernandes A, Tripathi SD, Barman I, Rajaram N, ACS Omega
- Noncontact diffuse reflectance spectroscopy of synovial fluid samples for rapid identification of infections
Drewke EE, Brand RL, Geels CG, Jensen HK, Wong K, Sanders JD, Rajaram N, Journal of Biophotonics
- Investigating the relationship between hypoxia, hypoxia-inducible factor (HIF-1), and the optical redox ratio in response to radiation therapy
Ivers JD, Puvvada N, Quick CM, Rajaram N, Biophotonics Discovery
- Racial and skin color mediated disparities in pulse oximetry in infants and young children
Sharma M, Brown A, Powell NM, Rajaram N, Tong L, Mourani PM, Schootman M, Pediatric Respiratory Reviews
- Acquired radiation resistance induces thiol-dependent cisplatin cross-resistance
Jenkins SV, Shah S, Jamshidi-Parsian A, Mortazavi A, Kristian H, Boysen G, Vang KB, Griffin RJ, Rajaram N, Dings RPM, Radiation Research
2023
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
Rodriguez Troncoso JI, Mim UM, Ivers JD, Paidi SK, Harper MG, Nguyen KG, Ravindranathan S, Rebello L, Lee DE, Zaharoff DA, Barman I, Rajaram N, Biomedical Optics Express
2022
- Diffuse reflectance spectroscopy of changes in tumor microenvironment in response to different doses of radiation
Jules AF, Means DA, Rodriguez Troncoso JI, Fernandes A, Dadgar S, Siegel ER, and Rajaram N, Radiation Research
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
Paidi SK, Rodriguez Troncoso JI, Harper MG, Liu Z, Nguyen KG, Ravindranathan S, Ivers JD, Zaharoff DA, Rajaram N, Barman I, Theranostics
- Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy
Bess SB, Greening GJ, Rajaram N, and Muldoon TJ, BMC Immunology
2021
- Raman spectroscopy and machine learning reveals early tumor microenvironmental changes induced by immunotherapy
Paidi SK, Rodriguez Troncoso JI, Raj P, Monterroso Diaz PM, Ivers JD, Lee DE, Avaritt NL, Gies AJ, Quick CM, Byrum SD, Tackett AJ, Rajaram N, Barman I, Cancer Research
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy.
Rodriguez Troncoso JI, Monterroso Diaz PM, Lee DE, Quick CM, Rajaram N, Biomedical Optics Express
- Mammary Tumors in Sprague Dawley Rats Induced by ENU for Evaluating Terahertz Imaging of Breast Cancer
Vohra N, Chavez Esparza T, Rodriguez Troncoso JI, Rajaram N, Wu J, Coan PN, Jackson T, Bailey K, and El-Shenawee, Journal of Medical Imaging
- Diffuse reflectance spectroscopy identifies heat stress-induced changes in hemoglobin concentration in chicken breast
Dadgar S, Greene ES, Dhamad A, Mallman B, Dridi S, and Rajaram N, Scientific Reports
- Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Capacity
Lee DE, Brown JL, Rosa-Caldwell ME, Perry RA, Brown LA, Haynie WS, Washington TA, Wiggs MP, Rajaram N, and Greene NP, Journal of Cachexia, Sarcopenia, and Muscle (JCSM) Rapid Communications
- Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors
Dadgar S, Rodriguez Troncoso JI, Siegel ER, Griffin RJ, Dings PM, Rajaram N, Neoplasia
2020
2019
- Optical imaging approaches to investigating radiation resistance
Dadgar S, Rajaram N. Frontiers in Oncology, Special Section on Radiation Oncology
- Quantum blue reduces the severity of Woody Breast myopathy via modulation of oxygen homeostasis-related genes in broiler chickens
Greene ES, Flees J, Dadgar S, Mallman B, Orlowski S, Rochell SJ, Kidd M, Whitefield H, Brearley C, Rajaram N, Walk C, Dridi S, Frontiers in Physiology
- Mitochondrial mRNA Translation Initiation Contributes to Oxidative Metabolism in the Myocardia of Aged, Obese Mice
Lee DE, Perry RA, Brown JL, Rosa-Caldwell ME, Brown LA, Haynie WS, Rajaram N, Washington TA, and Greene NP, Experimental Gerontology
- Label-free Raman spectroscopy reveals signatures of radiation resistance in the tumor microenvironment
Paidi SK,* Monterroso Diaz PM,* Dadgar S,* Jenkins SV, Quick CM, Griffin RJ, Dings RPM, Rajaram N, and Barman I, Cancer Research
2018
- Pulsed terahertz reflection imaging of tumors in a spontaneous model of breast cancer
Vohra N, Bowman T, Monterroso Diaz PM, Rajaram N, Bailey K, El-Shenawee M, Biomedical Physics and Engineering Express
- Tumor-derived granulocyte-colony stimulating factor diminishes efficacy of breast tumor cell vaccines
Ravindranathan S, Nguyen KG, Kurtz SL, Frazier HN, Smith SG, Koppolu B, Rajaram N, Zaharoff DA, Breast Cancer Research
- Rapid quantification of mitochondrial fractal dimension in individual cells
Vargas I, Alhallak K, Kolenc O, Jenkins SV, Griffin RJ, Dings PM, Rajaram N, Quinn KP, Biomedical Optics Express
- Sampling depth of a diffuse reflectance spectroscopy probe for in vivo physiologic quantification of murine subcutaneous tumor allografts
Greening GJ, Mundo A, Rajaram N, and Muldoon TJ, Journal of Biomedical Optics
- Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance
Monterroso Diaz PM, Jenkins SV, Alhallak K, Semeniak D, Griffin RJ, Dings RPM, and Rajaram N, Biomedical Optics Express
- A radiosensitizing inhibitor of HIF-1 alters the optical redox state of human lung cancer cells in vitro
Lee DE, Alhallak K, Jenkins SV, Lopez IV, Greene NP, Quinn KP, Griffin RJ, Dings RPM, and Rajaram N, Scientific Reports
- Optical spectroscopic sensing of tumor hypoxia
Dadgar S, Rodriguez Troncoso JI, and Rajaram N, Journal of Biomedical Optics (News article in Physics World)
- Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging
Martinez AF, McCachren SS III, Lee M, Murphy HA, Zhu C, Crouch BT, Martin HL, Erkanli A, Rajaram N, Ashcraft KA, Fontanella AN, Dewhirst MW, and Ramanujam N, Scientific Reports
- Pulsed terahertz imaging of breast cancer in freshly excised murine tumors
Bowman T, Chavez T, Khan K, Wu J, Chakraborty A, Rajaram N, Bailey K, and El-Shenawee M, Journal of Biomedical Optics
2017
2016
- Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism
Alhallak K, Rebello L, Muldoon TJ, Quinn KP, and Rajaram N, Biomedical Optics Express
- Multimodal imaging and spectroscopy fiber-bundle microendoscopy platform for non-invasive, in-vivo tissue analysis
Greening GJ, Rajaram N, and Muldoon TJ, Journal of Visualized Experiments
- Valve interstitial cell contractile strength and metabolic state are dependent on its shape
Lam NT, Muldoon TJ, Quinn KP, Rajaram N, and Balachandran K, Integrative Biology
- Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe
Greening GJ, James HM, Dierks MK, Osterholm S, Vongkittiargorn N, Rajaram N*, and Muldoon TJ*, Scientific Reports
- Optical molecular imaging and spectroscopy of oxygenation and metabolism in tumors
Im J and Rajaram N, IEEE Journal of Selected Topics in Quantum Electronics
2015
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium
Greening GJ, Powless AJ, Hutcheson JA, James HM, Dierks MK, Rajaram N, Muldoon TJ, Biomedical Optics Express
- Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue
Rajaram N, Reesor AF, Mulvey CS, Frees AE, Ramanujam N, PLoS ONE
2007 – 2014
- Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer
Frees AE, Rajaram N, McCachren SS III, Fontanella AN, Dewhirst MW, Ramanujam N, PLoS ONE
- Clinical study of noninvasive in vivo melanoma and non-melanoma diagnosis
Lim L, Nichols BS, Migden MR, Rajaram N, Reichenberg JS, Markey MK, Ross MI, Tunnell JW, Journal of Biomedical Optics
- Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe
Yu B, Shah A, Wang B, Rajaram N, Wang Q, Ramanujam N, Palmer GM, Dewhirst MW, Journal of Biophotonics
- Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm
Fontanella AN, Schroeder T, Hochman DW, Chen RE, Hanna G, Haglund MM, Rajaram N, Frees AE, Secomb TW, Palmer GM, Dewhirst MW, Microcirculation
- Delivery rate affects uptake of a fluorescent glucose analog in murine models of metastatic breast cancer
Rajaram N, Frees AE, Fontanella AN, Zhong J, Hansen K, Dewhirst MW, Ramanujam N, PLoS ONE
- Tethered inhibitors of hsp90 carrying optical or radio-iodinated probes reveal active internalization of ectopic hsp90 in breast tumor cells
Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector N, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Affleck DJ, Zalutsky MR, Lyerly HK and Haystead T, Chemistry and Biology
- Radiation induces aerobic glycolysis through reactive oxygen species
Zhong J, Rajaram N, Brizel DM, Frees AE, Ramanujam N, Batinic-Haberle I, Dewhirst MW, Radiotherapy and Oncology
- Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model
Liu C, Rajaram N, Vishwanath K, Jiang T, Palmer GM, Ramanujam N, Journal of Biomedical Optics
- Optimization of an experimental lookup table (LUT)-based approach to measuring optical properties of tissue
Nichols BS, Rajaram N, Tunnell JW, Journal of Biomedical Optics
- Development of a non-contact diffuse optical spectroscopy probe for measuring tissue optical properties
Bish SF, Rajaram N, Nichols BS, Tunnell JW, Journal of Biomedical Optics
- Changes in morphology and optical properties of sclera due to hyper-osmotic agent
Zaman RT, Rajaram N, Nichols BS, Rylander HG, Wang T, Tunnell JW, Welch AJ, Journal of Biomedical Optics
- Rapid and accurate determination of tissue optical properties using least-squares support vector machines
Barman I, Dingari NC, Rajaram N, Tunnell JW, Dasari RR, Feld MS, Biomedical Optics Express
- Probe pressure effects on human skin diffuse reflectance and intrinsic fluorescence spectroscopy measurements
Lim L, Nichols BS, Rajaram N, Tunnell JW, Journal of Biomedical Optics
- Variation of fluorescence in tissue with temperature
Zaman RT, Rajaram N, Walsh A, Oliver J, Rylander HG, Tunnell JW, Welch, AJ, Mahadevan-Jansen, A, Lasers in Surgery and Medicine
- Pilot clinical study for quantitative spectral diagnosis of non-melanoma skin cancer
Rajaram N, Reichenberg JS, Migden MR, Nguyen TH, Tunnell JW, Lasers in Surgery and Medicine
- Experimental validation of the effects of microvasculature pigment packaging on in vivo diffuse reflectance spectroscopy
Rajaram N, Gopal A, Zhang XJ, Tunnell JW, Lasers in Surgery and Medicine
- Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy
Rajaram N, Aramil T, Lee K, Reichenberg J, Nguyen TH, Tunnell JW, Applied Optics
- Lookup table-based inverse model for determining the optical properties of turbid media
Rajaram N, Nguyen TH, Tunnell JW, Journal of Biomedical Optics
- In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy
Zaman RT, Diagaradjane P, Wang JC, Swartz J, Rajaram N, Gill-Sharp KL, Cho SH, Rylander HG, Payne DJ, Krishnan S, Tunnell JW, IEEE Journal of Selected Topics in Quantum Electronics